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Ergosterol-depleted clinical isolates of <i>Nakaseomyces glabratus</i> can develop multi-drug resistance without apparent fitness and virulence defects

2025-08-28

Abstract excerpt

<h4>Objectives</h4> Nakaseomyces glabratus (formerly Candida glabrata ) is a leading cause of invasive candidiasis and rapidly develops antifungal drug resistance during treatment. An increasing number of clinical isolates shows reduced susceptibility to echinocandins and azoles, leaving amphotericin B (AMB) as a last therapeutic option. Resistance of N. glabratus to this drug is rare and its underlying mechani...

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Literature Corpus work
4a8ac3ad-875e-5d91-b5da-c9d6e522911c
DOI
10.1101/2025.08.28.672802
Open publication

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Ergosterol-depleted clinical isolates of <i>Nakaseomyces glabratus</i> can develop multi-drug resistance without apparent fitness and virulence defectsDOI 10.1101/2025.08.28.672802
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