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Structural Characterization of HIV gp41 with the Membrane-proximal External Region

5 Jun 2010

Abstract excerpt

Human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein (gp120/gp41) plays a critical role in virus infection and pathogenesis. Three of the six monoclonal antibodies considered to have broadly neutralizing activities (2F5, 4E10, and Z13e1) bind to the membrane-proximal external region (MPER) of gp41. This makes the MPER a desirable template for developing immunogens that can elicit antibodies with...

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PMID: 20525690
DOI: 10.1074/jbc.m110.111351

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