Article

Mitochondrial COA7 is a heme-binding protein involved in the early stages of complex IV assembly

2021-06-11

Abstract excerpt

Cytochrome c oxidase assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome c oxidase). Although mutations in COA7 have been linked in patients to complex IV assembly defects and neurological conditions such as peripheral neuropathy, ataxia and leukoencephalopathy, the precise role COA7 plays in the biogenesis of complex IV is not know...

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Literature Corpus work: 3e317166-0f46-51d5-bf9f-0cae530383b4
DOI: 10.1101/2021.06.10.447992

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