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Article

Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove.

Journal of molecular biology - 22 Apr 2011

Clark A R, Naylor C E, Bagnéris C, Keep N H, Slingsby C

Abstract excerpt

Small heat shock proteins form large cytosolic assemblies from an "α-crystallin domain" (ACD) flanked by sequence extensions. Mutation of a conserved arginine in the ACD of several human small heat shock protein family members causes many common inherited diseases of the lens and neuromuscular system. The mutation R120G in αB-crystallin causes myopathy, cardiomyopathy and cataract. We have solved the X-ray...

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Source

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Identifiers

PMID: 21329698
DOI: 10.1016/j.jmb.2011.02.020
PMCID: PMC3158665

Genes

ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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