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Article

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.

Neuron - 18 Oct 2023

Zheng Wang, Rawson Shaun, Shen Zhangfei, Tamilselvan Elakkiya, Smith Harper E, Halford Julia, Shen Chen, Murthy Swetha E, Ulbrich Maximilian H, Sotomayor Marcos, Fu Tian-Min, Holt Jeffrey R

Abstract excerpt

OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals, respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) proteins form homodimers with two pores. Here, we uncover an unanticipated monomeric configuration of TMEM63 proteins. Structures of TMEM63A and TMEM63B (referred to as TMEM63s) revealed a single highly restricted pore. Functional analyses demonstrated that...

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Interleukin-2
Ion Channels
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PMID: 37543036
DOI: 10.1016/j.neuron.2023.07.006
PMCID: PMC10592209

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