Article

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

2018-08-16

Abstract excerpt

The timely activation of homologous recombination is essential for the maintenance of genome stability, in which the RAD51 recombinase plays a central role. Biochemically, human RAD51 polymerises faster on single-stranded DNA (ssDNA) compared to double-stranded DNA (dsDNA), raising a key conceptual question: how does it discriminate between them? In this study, we tackled this problem by systematically assessing R...

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Literature Corpus work: e04e66c9-81a9-5b35-86ba-1ee099211c7e
DOI: 10.1101/392795

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