Article
Novel Pfk13 and Pfubp1 genotypes in African Plasmodium falciparum isolates exhibiting reduced susceptibility to the antimalarials artemisinin and lumefantrine.
mBio - 8 Apr 2026
Pratt Sade, van Schalkwyk Donelly A, Stewart Lindsay, Hocke Emma Filtenborg, Mannan Samirah, Berry Charlotte, Muwanguzi-Karugaba Julian, Nolder Debbie, Rogers Claire, Chiodini Peter L, Henrici Ryan C, Moss Sophie, Billows Nina, Phelan Jody, Clark Taane G, Campino Susana, Sutherland Colin J
Abstract excerpt
Recent evidence indicates that the clinical efficacy of the antimalarial combination artemether-lumefantrine may be compromised by emerging Plasmodium falciparum populations with reduced susceptibility to both components in some parts of East Africa. In vitro studies of parasites of Ugandan origin collected in the field and from imported cases in European travelers suggest that partial resistance to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.