Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study.

doi:10.1016/S2666-5247(24)00054-5

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Article

Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study.

The Lancet. Microbe - 1 Jul 2024

Joste Valentin, Coppée Romain, Bailly Justine, Rakotoarivony Yann, Toko Tchokoteu Francine Ghislaine, Achache Shany, Pradines Bruno, Cottrell Gilles, Ariey Frédéric, Khim Nimol, Popovici Jean, Mita Toshihiro, Groger Mirjam, Ramharter Michael, Egbo Timothy, Juma Dennis W, Akala Hoseah, Houzé Sandrine, Clain Jérôme

Abstract excerpt

BACKGROUND: Mutations in the Plasmodium falciparum dhfr gene confer resistance to pyrimethamine, which is widely used for malaria chemoprevention in Africa. We aimed to evaluate the frequency and evolution of dhfr mutations in Plasmodium ovale spp in Africa and their functional consequences, which are incompletely characterised. METHODS: We analysed dhfr mutations and their frequencies in P ovale spp isolates...

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PMID: 38761813
DOI: 10.1016/S2666-5247(24)00054-5

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