Article
Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda.
Nature communications - 4 Sept 2026
Asua Victor, Niaré Karamoko, Garg Shreeya, Legac Jenny, Tukwasibwe Stephen, Katairo Thomas, Bohissou Francis E, Crudale Rebecca M, Simkin Alfred, Mulondo Jerry, Nsobya Sam L, Ssewanyana Isaac, Dorsey Grant, Bailey Jeffrey A, Kamya Moses R, Yeka Adoke, Rosenthal Philip J, Borrmann Steffen, Conrad Melissa D
Abstract excerpt
Mutations in the Plasmodium falciparum genes, pfdhfr and pfdhps, drive antifolate resistance and threaten malaria control in regions where sulfadoxine-pyrimethamine (SP) is the primary chemoprevention strategy. The spatial patterns and evolutionary dynamics of these mutations in high-transmission settings remain incompletely understood. Here we genotyped 11 resistance-associated mutations in pfdhfr and pfdhps in...
Read the complete abstract on PubMedTopics
- Plasmodium falciparum
- Haplotypes
- Uganda
- Drug Resistance
- Humans