Article

Synthesizing Combination Therapies for Evolutionary Dynamics of Disease for Nonlinear Pharmacodynamics

2014-09-21

Abstract excerpt

Our previous results proposed an iterative scalable algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model with linear pharmacodynamics. In this manuscript, we use piecewise linear approximations to model nonlinear drug effects. We leverage results from optimal controller synthesis for positive systems to formulate the feedb...

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Literature Corpus work: e03ac7dd-f450-5057-a395-b59a05702691
DOI: 10.1101/009480

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