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Article

Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor

12 Sept 2017

Abstract excerpt

Glioblastoma (GBM) is a lethal tumor that displays remarkable genetic heterogeneity. It is also known that GBM contains a cell hierarchy driven by GBM stem-like cells (GSCs), responsible for tumor generation, therapeutic resistance, and relapse. An important and still open issue is whether phylogenetically related GSCs can be found in matched primary and recurrent GBMs, and reflect tumor genetic evolution under...

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PMID: 28895245
DOI: 10.1002/stem.2703

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