piRNA/ PIWI protein complex as potential biomarkers in sporadic amyotrophic lateral sclerosis

Abstract excerpt

<title>Abstract</title> <p>The pathological hallmark in the majority of amyotrophic lateral sclerosis (ALS) cases is the mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43), an RNA-binding protein. Several studies have attributed disease processes of ALS to abnormal RNA metabolism. However, dysregulated biogenesis of RNA, especially non-coding RNA (ncRNA), is poorly understood. To resolve it, R...

Topics

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• Amyotrophic Lateral Sclerosis
• Amyotrophic Lateral Sclerosis Research
• DNA-Binding Proteins
• MicroRNAs
• Mutation
• Neurogenetic and Muscular Disorders Research
• Neurological diseases and metabolism
• RNA-Binding Protein FUS

Identifiers and source

Literature Corpus work

e030764c-dcf0-5c40-85b6-0c564a4d69f8

DOI

10.21203/rs.3.rs-843093/v1