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Article

The dawn of pirna research in various neuronal disorders

1 Jan 2019

Abstract excerpt

Small non-coding PIWI-interacting RNAs (piRNAs) silence the expression of transposable elements integrated in a wide range of eukaryotic genomes in germline cells. Additionally, piRNAs regulate chromatin modifications, such as trimethylation of histone H3 lysine 9 (H3K9me3) or DNA methylation. In the past decade, the roles of piRNAs have been characterized in somatic cells, including post-mitotic neurons. More...

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PMID: 31136989
DOI: 10.2741/4789

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