Mosaic loss of chromosome Y is associated with common variation near TCL1A.

doi:10.1038/ng.3545

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Article

Mosaic loss of chromosome Y is associated with common variation near TCL1A.

Nature genetics - 1 May 2016

Zhou Weiyin, Machiela Mitchell J, Freedman Neal D, Rothman Nathaniel, Malats Nuria, Dagnall Casey, Caporaso Neil, Teras Lauren T, Gaudet Mia M, Gapstur Susan M, Stevens Victoria L, Jacobs Kevin B, Sampson Joshua, Albanes Demetrius, Weinstein Stephanie, Virtamo Jarmo, Berndt Sonja, Hoover Robert N, Black Amanda, Silverman Debra, Figueroa Jonine, Garcia-Closas Montserrat, Real Francisco X, Earl Julie, Marenne Gaelle, Rodriguez-Santiago Benjamin, Karagas Margaret, Johnson Alison, Schwenn Molly, Wu Xifeng, Gu Jian, Ye Yuanqing, Hutchinson Amy, Tucker Margaret, Perez-Jurado Luis A, Dean Michael, Yeager Meredith, Chanock Stephen J

Abstract excerpt

Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7% of men, and its prevalence increased with age (per-year odds ratio (OR) =...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27064253
DOI: 10.1038/ng.3545
PMCID: PMC4848121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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