Article

ß2-Arrestin germline knockout does not attenuate opioid respiratory depression

2020-08-28

Abstract excerpt

Opioids are perhaps the most effective analgesics in medicine. However, from 1999 to 2018, they also killed more than 400,000 people in the United States by suppressing breathing, a common side-effect known as opioid induced respiratory depression. This doubled-edged sword has inspired the dream of developing novel therapeutics that provide opioid-like analgesia without respiratory depression. One such approach ha...

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Literature Corpus work: e0296496-b941-5956-ae65-db233885ca35
DOI: 10.1101/2020.08.28.272575

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