How the complex pharmacology of the fentanyls contributes to their lethality

Abstract excerpt

Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to high potency and rapid onset of respiratory depression, these drugs also induce respiratory muscle stiffness, making it more difficult to breathe, are less sensitive than heroin to naloxone reversal and may show reduced cross-tolerance to other opioids. Overdose deaths...

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