Article
Morphine alters respiratory control but not other key obstructive sleep apnoea phenotypes: a randomised trial.
The European respiratory journal - 1 Jun 2020
Martins Rodrigo T, Carberry Jayne C, Wang David, Rowsell Luke, Grunstein Ronald R, Eckert Danny J
Abstract excerpt
Accidental opioid-related deaths are increasing. These often occur during sleep. Opioids such as morphine may worsen obstructive sleep apnoea (OSA). Thus, people with OSA may be at greater risk of harm from morphine. Possible mechanisms include respiratory depression and reductions in drive to the pharyngeal muscles to increase upper airway collapsibility. However, the effects of morphine on the four key...
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