Article

GWAS and multimodal transcriptomic profiling of human otolithic organs characterize the genetic architecture of balance in the elderly

2026-08-25

Abstract excerpt

Chronic dizziness affects up to 32% of those over 60. Although imbalance has a heritability of up to 47%, its genetic architecture is yet to be elucidated. We conducted a GWAS meta-analysis (n = 781,273; 96,517 cases), and identified 21 unique genes, including four related to memory, eight involved in function, and six expressed predominantly in the brain. Genomic structural equation modelling implicated dizziness...

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Literature Corpus work: e028ecd3-4e33-5a0c-918b-e83dfae39349
DOI: 10.64898/2026.08.21.26360655

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