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Article

Genome-wide analysis implicates inner ear development in Ménière disease.

American journal of human genetics - 2 Jul 2026

Shi Zhuozheng, Mandla Ravi, Li Jingjing, Li Xinzhe, Zhang Zixuan Eleanor, Chen Sixing, Lapinska Sandra, Flynn-Carroll Alexander O, Pasaniuc Bogdan, Epstein Douglas J, Mathieson Iain

Abstract excerpt

Ménière disease (MD) is a chronic inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, and tinnitus, but its etiology remains poorly understood. We performed a genome-wide meta-analysis of 8,969 MD case subjects and 1,962,542 control subjects across five biobanks, identifying five independent genome-wide significant loci and estimating an observed-scale SNP heritability...

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Identifiers

PMID: 42302782
DOI: 10.1016/j.ajhg.2026.05.011
PMCID: PMC13393102

Genes

ALDH1A2
CYP26A1
EYA1
EYA4
LMO4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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