Integrative genomic and single-cell transcriptomic analyses suggest a putative zinc transport-immune axis in Meniere's disease.

Abstract excerpt

Objective: Meniere's disease is a disabling inner-ear disorder whose molecular basis remains poorly understood. Immune dysregulation and genetic susceptibility have been implicated in disease etiology, but the genes and immune-cell programs linking genetic susceptibility to disease-associated molecular alterations remain incompletely defined. Focusing on zinc transport and immune signaling, we aimed to prioritize...

Topics

• Humans
• Meniere Disease
• Single-Cell Gene Expression Analysis
• Genome-Wide Association Study
• Single-Cell Analysis
• Zinc