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The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila

14 Oct 2017

Abstract excerpt

Tissue fibrosis, an accumulation of extracellular matrix proteins such as collagen, accompanies cardiac ageing in humans and this is linked to an increased risk of cardiac failure. The mechanisms driving age-related tissue fibrosis and cardiac dysfunction are unclear, yet clinically important. Drosophila is amenable to the study of cardiac ageing as well as collagen deposition; however it is unclear whether...

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PMID: 29032244
DOI: 10.1016/j.exger.2017.10.011

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