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Article

Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts.

Scientific reports - 12 Nov 2020

Hsu Wei-Hsiang, Lin Bing-Ze, Leu Jyh-Der, Lo Pin-Ho, Yu Hsueh-Yen, Chen Chao-Tsung, Tu Yuan-Heng, Lin Yun-Lian, Lee Yi-Jang

Abstract excerpt

Herbal medicines are attractive agents for human care. In this study, we found that the alcohol extract of Ajuga taiwanensis (ATE) screened from a chemical bank exhibited potent capacity for suppressing senescence associated biomarkers, including SA-β-gal and up-regulated p53 in old human dermal fibroblasts (HDFs) without induction of significant cytotoxicity up to 100 µg/ml. Concomitantly, cells re-entered the...

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PMID: 33184359
DOI: 10.1038/s41598-020-76797-6
PMCID: PMC7661503

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