Article

Chromone scaffold–mediated reprogramming of the epithelial–mesenchymal transition prevents fibrosis

2017-02-16

Abstract excerpt

<h4>Summary</h4> Fibrotic diseases are major causes of morbidity and mortality, and the epithelial–mesenchymal transition (EMT) plays a central role in the development of tissue/organ fibrosis. We discovered that eupatilin, a member of the chromone scaffold (CS)-containing compounds found ubiquitously in the plant kingdom, completely reversed fibrogenesis in vitro and substantially ameliorated bleomycin-induced...

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Literature Corpus work: 1e86cce3-2fab-5c33-b8e2-4764a241e54b
DOI: 10.1101/106591

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