Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted loss of heterozygosity in Candida albicans using CRISPR-Cas9 reveals the functional impact of allelic variation.

Genetics - 8 Oct 2025

Després Philippe C, Gervais Nicholas C, Fogal Meea, Rogers Ruby K J, Cuomo Christina A, Shapiro Rebecca S

Abstract excerpt

The diploid genome of the fungal pathogen Candida albicans is highly heterozygous, with most allele pairs diverging at either the coding or regulatory level. When faced with selection pressure like antifungal exposure, this hidden genetic diversity can provide a reservoir of adaptive mutations through loss of heterozygosity (LOH) events. Validating the potential phenotypic impact of LOH events observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candida albicans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Drug Resistance, Fungal

Share to Gene Editing

Share to Genome, Fungal

Share to Loss of Heterozygosity

Share to RNA, Guide, CRISPR-Cas Systems

Source

Open in PubMed Open full text

Identifiers

PMID: 40794772
DOI: 10.1093/genetics/iyaf154
PMCID: PMC12505295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted loss of heterozygosity in Candida albicans using CRISPR-Cas9 reveals the functional impact of allelic variation.PMID 40794772Read ↗

Targeted loss of heterozygosity in <i>Candida albicans</i> using CRISPR-Cas9Semantic proximity Read ↗

CRISPR-Cas9 editing induces Loss of Heterozygosity in the pathogenic yeast <i>Candida parapsilosis</i>Semantic proximity Read ↗

Allele-specific genome editing using CRISPR-Cas9 causes off-target mutations in diploid yeastSemantic proximity Read ↗

Candida albicans: a historical overview of investigations into an important human pathogenSemantic proximity Read ↗

Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome.Semantic proximity Read ↗

The CRISPR toolbox in medical mycology: State of the art and perspectivesSemantic proximity Read ↗

An Efficient, Rapid, and Recyclable System for CRISPR-Mediated Genome Editing in Candida albicansSemantic proximity Read ↗

The Genome of the Human Pathogen <i>Candida albicans</i> is Shaped by Mutation and Cryptic Sexual RecombinationSemantic proximity Read ↗

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicansSemantic proximity Read ↗

Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survivalSemantic proximity Read ↗

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual RecombinationSemantic proximity Read ↗

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.