Article

Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats

2021-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale and Objective</h4> Pain-related factors increase risk for opioid addiction, and opioid-induced pain relief may function as a negative reinforcer to increase opioid taking and seeking. However, experimental pain-related manipulations generally do not increase opioid self-administration in rodents. This discrepancy may reflect insufficient learning of pain-relief contingencies or co...

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Literature Corpus work: e00e1444-6abf-5b92-b3f8-b46aa5676f8f
DOI: 10.1101/2021.02.11.430808

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