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Article

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord.

British journal of pharmacology - 1 Jan 2015

Kao Jen-Hsin, Gao Man-Jun, Yang Pao-Pao, Law Ping-Yee, Loh Horace H, Tao Pao-Luh

Abstract excerpt

BACKGROUND AND PURPOSE: Opioid antagonists, such as naloxone and naltrexone, exhibit agonistic properties at the mutated μ receptor, MOR-S196ACSTA. In our previous study, systemic naloxone (10 mg·kg(-1) , s.c.) elicited antinociceptive effect without the induction of tolerance, dependence or rewarding effect in mice 2 weeks after intrathecal administration of double-stranded adeno-associated...

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Identifiers

PMID: 24866991
DOI: 10.1111/bph.12790
PMCID: PMC4292974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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