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Article

Compulsive methamphetamine taking under punishment is associated with greater cue-induced drug seeking in rats.

Behavioural brain research - 30 May 2017

Torres Oscar V, Jayanthi Subramanian, Ladenheim Bruce, McCoy Michael T, Krasnova Irina N, Cadet Jean Lud

Abstract excerpt

Methamphetamine (METH) addicts lose control over drug consumption despite suffering multiple adverse medicolegal consequences. To mimic the negative events associated with drug addiction in humans, we recently introduced a rat model of self-administration (SA) with response-contingent punishment on METH intake. These procedures allowed us to distinguish between two addiction-like phenotypes in rats, those that...

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Identifiers

PMID: 28284948
DOI: 10.1016/j.bbr.2017.03.009
PMCID: PMC7605116

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