Article

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

2022-10-25

Abstract excerpt

<h4>Background</h4> We previously reported inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity in 1-5% of unvaccinated patients with life-threatening COVID-19, and auto-antibodies against type I IFN in another 15-20% of cases. <h4>Methods</h4> We report here a genome-wide rare variant burden association analysis in 3,269 unvaccinated patients with life-threatening COVID-19 (1,301 previously...

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Literature Corpus work: e0059e99-687a-5657-a52c-7e05f9fa70b4
DOI: 10.1101/2022.10.22.22281221

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