Article

Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19

2020-12-20

Abstract excerpt

A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole-genome sequencing of 1,934 COVID-19 cases (713 with severe and 1,221 with mild disease) and 15,251 ancestry-matched population controls across four independent COVID-19 biobanks. We then te...

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Literature Corpus work: 93c894d0-a73b-5cee-b44f-3d47a42cd376
DOI: 10.1101/2020.12.18.20248226

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