Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

5 Apr 2023

Abstract excerpt

Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Immune responses and vaccinations
Share to Immunodeficiency and Autoimmune Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37020259
DOI: 10.1186/s13073-023-01173-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19PMID 37020259Read ↗

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19Semantic proximity Read ↗

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19.Semantic proximity Read ↗

Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19Semantic proximity Read ↗

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.Semantic proximity Read ↗

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).Semantic proximity Read ↗

Rare Variants in Inborn Errors of Immunity Genes Associated with Covid-19 SeveritySemantic proximity Read ↗

Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common VariantsSemantic proximity Read ↗

Rare Variants in Inborn Errors of Immunity Genes Associated With Covid-19 Severity.Semantic proximity Read ↗

Stratified analyses refine association between TLR7 rare variants and severe COVID-19.Semantic proximity Read ↗

Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19?Semantic proximity Read ↗

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19.Semantic proximity Read ↗

The seven enigmas of SARS-CoV-2: From the past to the futureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.