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The seven enigmas of SARS-CoV-2: From the past to the future

24 Sept 2025

Abstract excerpt

Five years ago, we launched the COVID Human Genetic Effort. Our goal was to explain the clinical variability among SARS-CoV-2-exposed individuals by searching for monogenic inborn errors of immunity (IEI) and their phenocopies. We deciphered the pathogenesis of critical COVID-19 pneumonia and multisystemic inflammatory syndrome in children (MIS-C) in ~15% and 2% of cases, respectively, thereby revealing general...

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PMID: 41347066
DOI: 10.70962/jhi.20250149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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