Article

Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1

2023-12-26

Abstract excerpt

<title>Abstract</title> Neutrophils can be beneficial or deleterious during tuberculosis (TB). Based on the expression of MHC-II and programmed death ligand 1 (PD-L1), we distinguished two functionally and transcriptionally distinct neutrophil subsets in the lungs of mice infected with mycobacteria. Inflammatory [MHC-II−, PD-L1lo] neutrophils produced inflammasome-dependent IL-1β in the l...

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Literature Corpus work: e0056b1b-a487-5ba6-9069-18007e3e4c8b
DOI: 10.21203/rs.3.rs-3786084/v1

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