Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis.

doi:10.1016/j.tube.2026.102786

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Article

Context-dependent transcriptional and epigenetic reprogramming shapes neutrophil antimicrobial and immunoregulatory functions in tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2026

Almeida Cicero José Luíz Dos Ramos, Castro Ricardo Cardoso, Cardoso-Silva Priscilla Mariane, Zambuzi Fabiana Albani, Silva Patrick Fernandes, Brauer Veronica Soares, Gravina Humberto Dorigetto, Fontanari Caroline, Bollela Valdes Roberto, Frantz Fabiani Gai

Abstract excerpt

Inflammatory microenvironments regulate immune cell differentiation, activation, and programming. Although traditionally considered terminally differentiated effectors, neutrophils can acquire distinct functional states in response to environmental cues. To examine context-dependent neutrophil programming, cells from healthy donors were cultured in vitro under cytokine regimens mimicking opposing inflammatory...

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Topics

Humans
Neutrophils
Mycobacterium tuberculosis
Epigenesis, Genetic
Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Transcription, Genetic

Cytokines

DNA Methylation

Reactive Oxygen Species

Tuberculosis

Host-Pathogen Interactions

Immunity, Innate

Phenotype

Signal Transduction

Trained Immunity

Source

Open in PubMed

Identifiers

PMID: 42296595
DOI: 10.1016/j.tube.2026.102786

Genes

TLR4
CCR7
CD86
DNMT3A
TLR2
TNF

Provenance

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