Article
In tuberculous pleural effusions, activated neutrophils undergo apoptosis and acquire a dendritic cell-like phenotype.
The Journal of infectious diseases - 1 Aug 2005
Aleman Mercedes, de la Barrera Silvia S, Schierloh Pablo L, Alves Leandro, Yokobori Noemi, Baldini Matias, Abbate Eduardo, Sasiain Maria C
Abstract excerpt
Tuberculous pleuritis usually shows lymphocytic preponderance, but neutrophils are also present. Therefore, pleuritis is a good model for the study of neutrophil fate at sites of active Mycobacterium tuberculosis infection. We have previously demonstrated in vitro that M. tuberculosis-induced neutrophil apoptosis involves p38 mitogen protein kinase activation through Toll-like receptor 2. Herein, we demonstrate...
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