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The Adaptive Compromise Hypothesis: Host Accommodation to Pathogen Exploitation of Neutrophil Defenses in Tuberculosis

2026-06-23

Abstract excerpt

Tuberculosis (TB) remains the world's leading infectious cause of mortality. The traditional view holds that neutrophils protect the host against Mycobacterium tuberculosis through NADPH oxidase 2 (NOX2)-derived reactive oxygen species (ROS), and that more neutrophil activity equals greater protection. However, two discoveries fundamentally challenge this linear model. First, M. tuberculosis can exploit neutrophil...

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Literature Corpus work
695b0202-e240-5bae-bc49-1b3ba1d3972c
DOI
10.32388/5i9sqw
Open publication

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