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Evaluation of a Bayesian hierarchical pharmacokinetic-pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugs

2024-04-15

Abstract excerpt

The rise of multidrug resistant malaria requires accelerated development of novel antimalarial drugs. Pharmacokinetic-pharmacodynamic (PK-PD) models relate blood antimalarial drug concentrations with the parasite-time profile to inform dosing regiments. We performed a simulation study to assess the utility of a Bayesian hierarchical mechanistic PK-PD model for predicting parasite-time profiles for a Phase 2 study...

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Literature Corpus work
dfb84c2d-66d5-5983-a1c2-cbb8b7b1b10d
DOI
10.1101/2024.04.14.24305810
Open publication

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Evaluation of a Bayesian hierarchical pharmacokinetic-pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugsDOI 10.1101/2024.04.14.24305810
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