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Article

Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria.

CPT: pharmacometrics & systems pharmacology - 1 Jan 2022

Sae-Heng Teerachat, Rajoli Rajith Kumar Reddy, Siccardi Marco, Karbwang Juntra, Na-Bangchang Kesara

Abstract excerpt

Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions. The study aimed to predict the potential dose regimens of quinine when coadministered with phenobarbital in adult patients with cerebral malaria and complications (e.g., lactic...

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Identifiers

PMID: 34730282
DOI: 10.1002/psp4.12737
PMCID: PMC8752110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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