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Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood stage<i>Plasmodium falciparum</i>

2024-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The combination antimalarial artefenomel-piperaquine failed to achieve target efficacy in a phase 2b study in Africa and Vietnam. We retrospectively evaluated whether characterizing the pharmacological interaction of this antimalarial combination in a volunteer infection study (VIS) would have enabled prediction of the phase 2b study results. <h4>Methods</h4> Twenty-four healt...

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Literature Corpus work
fc970a8c-91bb-568a-9d34-feb015849049
DOI
10.1101/2024.02.07.24302432
Open publication

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Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood stage<i>Plasmodium falciparum</i>DOI 10.1101/2024.02.07.24302432
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