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Article

Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology.

PLoS medicine - 1 May 2024

Mousa Andria, Cuomo-Dannenburg Gina, Thompson Hayley A, Chico R Matthew, Beshir Khalid B, Sutherland Colin J, Schellenberg David, Gosling Roly, Alifrangis Michael, Hocke Emma Filtenborg, Hansson Helle, Chopo-Pizarro Ana, Mbacham Wilfred F, Ali Innocent M, Chaponda Mike, Roper Cally, Okell Lucy C

Abstract excerpt

BACKGROUND: Recently revised WHO guidelines on malaria chemoprevention have opened the door to more tailored implementation. Countries face choices on whether to replace old drugs, target additional age groups, and adapt delivery schedules according to local drug resistance levels and malaria transmission patterns. Regular routine assessment of protective efficacy of chemoprevention is key. Here, we apply a novel...

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Identifiers

PMID: 38723040
DOI: 10.1371/journal.pmed.1004376
PMCID: PMC11081503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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