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Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization

4 Sept 2013

Abstract excerpt

Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which were too low, particularly for high-risk groups such as young children and pregnant women. This may accelerate the emergence and spread of resistance, thereby shortening the useful life of the drug, but it is an inevitable consequence of the current imprecise method of dose finding. An alternative approach to dose...

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PMID: 24002099
DOI: 10.1128/aac.00287-13

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