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Physiologically-based Pharmacokinetic (PBPK) Modeling for Prediction of the Optimal Dose Regimens of Quinine and Phenobarbital Co-administration in Adult Patients with Cerebral Malaria and Seizures

2020-08-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Cerebral malaria is a fatal disease. Patients with cerebral malaria are at risk of seizure development, therefore, the co-administration of antimalarial and antiepileptic drugs are needed. Quinine and phenobarbital are standard drugs for the treatment of cerebral malaria with seizures. However, there is no information on the optimal dosage regimens of both drugs...

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Literature Corpus work
8cc151fc-382c-5861-a1b6-851ad13de2f2
DOI
10.21203/rs.3.rs-53474/v1
Open publication

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Physiologically-based Pharmacokinetic (PBPK) Modeling for Prediction of the Optimal Dose Regimens of Quinine and Phenobarbital Co-administration in Adult Patients with Cerebral Malaria and SeizuresDOI 10.21203/rs.3.rs-53474/v1
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