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Article

Cluster analysis reveals three clinical phenotypes of pulmonary artery hypertension associated with connective tissue diseases: insights into inflammation and immunity.

Arthritis research & therapy - 5 Apr 2025

Wu Qianwen, Li Dongyu, Ye Huangshu, Zhou Zhangdi, Zhang Yixin, Zhang Miaojia, Sun Xiaoxuan, Wang Qiang

Abstract excerpt

BACKGROUND: Inflammation and immune mechanisms play a crucial role in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), though they remain inadequately understood. This study aimed to identify specific clinical phenotypes in CTD-PAH using inflammatory and immune markers through hierarchical cluster analysis. METHODS: We conducted a single-center, retrospective cohort study of CTD-PAH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40188060
DOI: 10.1186/s13075-025-03545-4
PMCID: PMC11971762

Genes

PAH
C3
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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