Article
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging
22 Nov 2022
Abstract excerpt
Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and increases the risk of many aging-related metabolic diseases. Here, we report phenotypic and single-nucleus transcriptomic analyses of non-human primate skeletal muscle aging. A higher transcriptional fluctuation was observed in myonuclei relative to other interstitial cell types, indicating a higher susceptibility of skeletal...
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