Article
FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS.
Molecular neurobiology - 1 Dec 2022
Zhou Binbin, Zheng Yilei, Li Xiaobing, Dong Huifang, Yu Jiaxi, Zou Yang, Zhu Min, Yu Yanyan, Fang Xin, Zhou Meihong, Zhang Wei, Yuan Yun, Wang Zhaoxia, Deng Jianwen, Hong Daojun
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by dysfunction of the upper and lower motor neurons resulting in muscle weakness and wasting. Recently, several studies on ALS patients and ALS animal models indicated that intramuscular toxicity played a role in ALS disease progression; however, the mechanisms driving this are unknown. In this study, we explored the...
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