Article

Branch-resolved IFN/STING-linked lesion-state architecture in psoriasis: multi-cohort derivation, held-out bulk replication and single-cell context analysis

2026-07-22

Abstract excerpt

<h4>Objective and design</h4> We tested whether a frozen branch-resolved IFN/STING-linked lesion-state architecture derived from paired psoriasis transcriptomes would transport to an untouched bulk RNA-sequencing cohort and remain detectable within broad cell compartments. <h4>Material or subjects</h4> Seven paired bulk cohorts formed the derivation backbone. GSE121212 provided held-out replication using 27 matc...

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Literature Corpus work: df579af5-c6ad-5611-ab52-e0d6c76d034e
DOI: 10.64898/2026.07.19.739418

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