Article

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

2017-08-08

Abstract excerpt

Coronaviruses encode a mix of highly conserved and novel genes as well as genetic elements necessary for infection and pathogenesis, raising the possibility for common targets for attenuation and therapeutic design. In this study, we focus on the highly conserved nonstructural protein (NSP) 16, a viral 2’O methyl-transferase (MTase) that encodes critical functions in immune modulation and infection. Using reverse...

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Literature Corpus work: df4747a9-9b7a-51ec-a6c5-9bcf0f273396
DOI: 10.1101/173286

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