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A live attenuated SARS-CoV-2 vaccine constructed by dual inactivation of NSP16 and ORF3a

25 Mar 2025

Abstract excerpt

BACKGROUND: Live attenuated vaccines against SARS-CoV-2 activate all phases of host immunity resembling a natural infection and they block viral transmission more efficiently than existing vaccines in human use. In our prior work, we characterised an attenuated SARS-CoV-2 variant, designated d16, which harbours a D130A mutation in the NSP16 protein, inactivating its 2'-O-methyltransferase function. The d16...

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PMID: 40132472
DOI: 10.1016/j.ebiom.2025.105662

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