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Article

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.

Journal of virology - 1 Sept 2018

Menachery Vineet D, Gralinski Lisa E, Mitchell Hugh D, Dinnon Kenneth H, Leist Sarah R, Yount Boyd L, McAnarney Eileen T, Graham Rachel L, Waters Katrina M, Baric Ralph S

Abstract excerpt

With an ongoing threat posed by circulating zoonotic strains, new strategies are required to prepare for the next emergent coronavirus (CoV). Previously, groups had targeted conserved coronavirus proteins as a strategy to generate live attenuated vaccine strains against current and future CoVs. With this in mind, we explored whether manipulation of CoV NSP16, a conserved 2'O methyltransferase (MTase), could...

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Identifiers

PMID: 29976657
DOI: 10.1128/JVI.00710-18
PMCID: PMC6096805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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