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Article

Mutations in feline infectious peritonitis virus nonstructural protein 14/16 methyltransferase attenuate the pathogenicity of the virus in cats.

Journal of virology - 23 Oct 2025

Jiao Zhe, Li Jia, Wang Pengpeng, Yan Yuanyuan, Fang Lingying, Chen Yuanyuan, Hu Xiaoshuai, Shi Yuejun, Peng Guiqing

Abstract excerpt

Feline infectious peritonitis virus (FIPV) can cause an immune-mediated disease that is fatal to felines, but there is a lack of clinically effective protection conferred by vaccines. The methyltransferase (MTase) activity of the coronavirus nonstructural proteins nsp14 and nsp16 affects virulence, but there are no studies on the effect of nsp14 and nsp16 mutations affecting enzyme activity on the virulence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40923786
DOI: 10.1128/jvi.00839-25
PMCID: PMC12548424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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