Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Nature - 4 May 2006

Kwok Trevor C Y, Ricker Nicole, Fraser Regina, Chan Allen W, Burns Andrew, Stanley Elise F, McCourt Peter, Cutler Sean R, Roy Peter J

Abstract excerpt

Small-molecule inhibitors of protein function are powerful tools for biological analysis and can lead to the development of new drugs. However, a major bottleneck in generating useful small-molecule tools is target identification. Here we show that Caenorhabditis elegans can provide a platform fo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Calcium Channel Blockers
Share to Calcium Channels, L-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Oviposition

Share to Phenotype

Share to Pyridines

Source

Identifiers

PMID: 16672971
DOI: 10.1038/nature04657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16672971-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A small-molecule screen in C. elegans yields a new calcium channel antagonist.PMID 16672971Read ↗

Gαq Mediates Clozapine Effects in <i>Caenorhabditis</i> elegansSemantic proximity Read ↗

A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug TargetSemantic proximity Read ↗

Drug discovery: Insights from the invertebrate Caenorhabditis elegansSemantic proximity Read ↗

Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans.Semantic proximity Read ↗

SARS-CoV-2 Entry Can Be Mimicked in <em>C. elegans</em> Expressing Human ACE2: A New Tool for Pharmacological StudiesSemantic proximity Read ↗

A rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders.Semantic proximity Read ↗

Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia.Semantic proximity Read ↗

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic ActivitySemantic proximity Read ↗

The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans.Semantic proximity Read ↗

Transient receptor potential melastatin (TRPM) channels mediate clozapine-induced phenotypes in Caenorhabditis elegans.Semantic proximity Read ↗

Therapeutic target discovery using Caenorhabditis elegans.Semantic proximity Read ↗

Functional analysis of epilepsy-associated GABAA receptor mutations using Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.